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Best Dermal Fillers For YOUR Face 2023 (with the science)All of the currently available HA fillers are indicated by the FDA for injection into the mid to deep dermis for the correction of either moderate to severe. PDF | Injectable fillers were introduced in dermatology as a method for reconstructing facial deformities and restoring the aging face. This document provides an overview of the structure and function of skin, as well as the process of skin aging. It discusses the key layers and components.